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Biomaterials, 282 (2022)

Any discussion of specific peptides or potential research findings is informational only and must not be interpreted as guidance for use in or on humans or animals.

Due to its reducibility, GSH can reduce many high-valence transition metal ions to their corresponding low-valence states, such as Fe (III)/Fe (II), Cu (II)/Cu(I), Ce(IV)/Ce(III), Mn(IV)/Mn(II), and Co(III)/Co(II)

Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinsons disease

Collectively, these findings support the notion that LPCAT3 serves not only as a core lipid remodeling enzyme in the ferroptosis cascade but also as a disease-specific modulator of immune-metabolic interactions in OA