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Nature 500 (7464), 541546

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This parameter has been further studied, showing that those men and women in the lowest quartile of the IGF-1/IGFBP3 ratio are threefold more likely to meet the Adult Treatment Panel III (ATP-III) definition for MetS, and twice as likely to be insulin resistantthat IGF-1/IGFBP-3 ratio decreases notably as the number of MetS components increases [217]

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doi: 10.1016/j.phrs.2020.105080 31 LiCLiLYangMYangJZhaoCHanYet al

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63 Rodrguez-ColmanM

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Extended Data Figure 8 Pharmacokinetic analysis of teixobactin

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The fatty acid acylation of cagrilintide enables albumin binding in circulation, reducing renal clearance and extending the elimination half-life to support once-weekly dosing

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