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Thus, when doses of drugs are higher than normal levels of conjugating molecules, saturation of metabolism occurs and the unconjugated drug/metabolite precipitates toxicity

Pharmacol Rev 41:143210 Corpas FJ, Barroso JB, Carreras A, Valderrama R, Palma JM, Len AM, Sandalio LM, del Ro LA (2006) Constitutive arginine-dependent nitric oxide synthase activity in different organs of pea seedlings during plant development

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