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It can be depleted quickly if a person is sick, has been working out vigorously, heavily drinking or smoking in turn, making you susceptible to illness

3) proliferation

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Among its types, pigment stones, primarily composed of bilirubin, arise due to disruptions in bilirubin metabolism

Hepatotoxicity would be shown to be a consequence of CYP-mediated metabolism to NAPQI and differences in this metabolic pathway are a key determinant of relative sensitivity to its hepatotoxicity