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Third, we need to exploit the neuroprotective effects of intravenous anesthesia and avoid the neurotoxic effects to better guide the clinical practice of intravenous anesthesia

10.1007/s00586-010-1619-z 89 GaoF.MaoT.SunW.GuoW.WangY.LiZ.et al (2015)

Volume of Distribution The apparent volume of distribution reflects a balance between binding to tissues, which decreases plasma concentration and makes the apparent volume larger, and binding to plasma proteins, which increases plasma concentration and makes the apparent volume smaller