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Different combinations and sequences of amino acids give rise to the enormous diversity of proteins found in nature

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Recently, some studies have documented that TMAO was associated with the occurrence, progression, recurrence, and embolism risk of atrial fibrillation (AF)

moreover, l-ARG has been found to play a relevant positive impact on atherosclerosis, as demonstrated by two RCTs showing that administration of l-ARG improved endothelium-dependent vasodilation of brachial [55] and coronary arteries [56] in patients with angiographically reported coronary artery disease