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Similar results have also been shown in rat models investigating the healing of the medial collateral ligament (MCL) following surgical transection (Cerovecki et al
Triple-negative breast cancer (TNBC) and KRAS-mutant pancreatic cancer often exhibit significant Gln addiction, with survival rates positively correlated to Gln metabolic activity
Of note, this pathway of arginine-induced efferocytosis (with arginine derived from engulfed apoptotic cells) is complemented by efferocytosis-induced glycolysis dependent on activation of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2), triggering enhanced binding of apoptotic cells to the macrophage cell surface via glycolysis-derived lactate (Schilperoort et al., 2023)
10.1016/j.ejpb.2016.11.026 28 CedrowskaE.PruszynskiM.GawedaW.ZukM.KrysinskiP.BruchertseiferF.et al (2020)
doi: 10.3390/ijms20081833
VIP and airway function VIP is essential for normal lung function
