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Description

Glucose stimulates the activity of insulin transcription factors pancreatic and duodenal homeobox 1 (PDX-1), neurogenic differentiation 1 (NEUROD1)E47 and MafA at multiple levels, including changes in their expression levels, subcellular localisation, DNA-binding activity, transactivation capability and interactions with other proteins

Regulation of LC3 lipidation by the autophagy-specific class III phosphatidylinositol-3 kinase complex

364 The metabolic reprogramming is characterized by shifting glucose metabolism to aerobic glycolysis, including enhanced cytosolic lactate fermentation and PPP and decreased OXPHOS

Himmelfarb J, Tuttle KR

Their operation is also precisely controlled by many regulators, but even under the conditions of so many pathways, more and more studies still regard SLC7A11 as the rate-limiting precursors and GPX4 as the core antioxidant defense to against ferroptosis ( Association between obesity and ferroptosis Studies found that obesity is closely related to iron metabolism disorders, which are mainly reflected as an excessive iron level (59)