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However, the long-term systemic effects of chronic NNMT inhibition on methylation pathways, liver function, and cardiovascular health have not been studied
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In the pivotal 2018 animal study by Neelakantan et al., systemic treat Mechanism of Action 5-Amino-1MQ inhibits NNMT (nicotinamide N-methyltransferase), an enzyme that catalyzes the N-methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor, producing 1-methylnicotinamide (MNA) and S-adenosylhomocysteine (SAH) as products
Cognitive changes : NAD+ supports brain cell metabolism and DNA repair
