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Free water imaging, calculated from diffusion weighted MRI, separating the diffusion properties within tissue from those in the extracellular space, can also be used as a measure of SN dopaminergic neuronal degeneration in PD, where increases in extracellular space correspond to loss of neurons 51

For example, 8 weeks on followed by 4 weeks off, or 12 weeks on followed by 6 weeks off

they also function as educational documents that help practitioners explain treatments to their clients

In the proximal segment of the small bowel, the fluid transparency difference did not reach statistical significance (p = 0.1, Figure 1A)

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R2 R3 hexanoyl Tyr He pb heptanoyl Tyr He Pb pentanoyl Tyr He pb butanoyl Tyr He pb propanoyl Tyr He pb acetanoyl Tyr He pb benzoyl Tyr He pb hexanoyl Tyr lie tyrosine and isoleucine at R2 and R 3 , respectively a wide range of amino acid and other residues might be used for the mimetics or agonists (Family 1 and Families 2- 5, respectively) in the practice of embodiments of the invention at these other positions including, without limitation, tyrosine, cysteine, methionine, phenylalaine, aspartic acid, glutamic acid, histidine, tryptophan, lysine, leucine, valine, homocysteine, homoserine, and homophenyalanine