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According to the National Institutes of Health (NIH), jaundice in acetaminophen overdose cases indicates critical liver impairment that requires emergency care
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In the first reaction, methylmalonic acid is converted to succinyl-CoA using vitamin B 12 as a cofactor (Figure 1)

85, 33183325.10.1002/jnr.21208 107 OndoJ

Nevertheless, if left untreated or if the infection spreads, it can progress to an upper urinary tract infection, affecting the kidneys and thus developing pyelonephritis
