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The increase in endogenous SO 2 may serve a compensatory role when the H 2 S/CSE pathway is downregulated in MCT-induced PH, thereby providing protective effects against endothelial inflammatory responses (Zhang D

Adv Pharmacol 38:247269

[DOI] [PubMed] [Google Scholar] 58.Clark SL., Jr Cellular differentiation in the kidneys of newborn mice studies with the electron microscope

(ii) the second line of defence: enzymatic antioxidant and antioxidant molecules that scavenge the generated ROS

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In addition, Hcy induced inflammation in the mouse retina, brain, and cultured human monocytes (U837)