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All statistical analyses were performed using IBM SPSS version 22 statistical software (IBM SPSS, Chicago, IL, USA)

doi: 10.1046/j.1600-0404.2003.00227.x

This is the future for the approximately 30% of the 1.9 million individuals in the United States diagnosed with UC including nearly 600000 children, adolescents, and young adults who are projected to become refractory to all immunosuppressive therapies, ultimately requiring surgical removal of their entire large intestine[55-58]

5f), shown to be crucial for signaling between the membrane-spanning and nucleotide-binding domains 58

doi: 10.1016/j.nbd.2008.11.005

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