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Apoptotic cell death is an important cause of neuronal injury in experimental Venezuelan equine encephalitis virus infection of mice

Secondary metabolic markers include fasting glucose, insulin sensitivity via HOMA-IR or glucose tolerance testing, body composition changes (DEXA scan or MRI for fat mass and lean mass distribution), mitochondrial respiration capacity via Seahorse analyzer, and serum markers like HbA1c for long-term glucose control

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For instance, studies have shown that PPA administration increases oxidative stress and induces ASD-like behaviors in rodents while elevating pro-inflammatory cytokine levels, such as IL-6, and impairing locomotor activity (MacFabe et al

Libraries were integrated using the sctransform workflow in Seurat 37