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170 Compared with normal tissues, caveolin-1 (CAV1) expression is upregulated and associated with poor prognosis in HNSCC patients, and negatively correlated with ROS level

The same results were observed for Akemi, Amorphous silica, and Doxorubicin in Laboratory 1, in contrast to Laboratory 2 which observed changes induced by those chemicals at high concentrations (Table 5

Targeting mitochondrial iron metabolism suppresses tumor growth and metastasis by inducing mitochondrial dysfunction and mitophagy

These improvements reflect reduced cardiovascular risk and validate the metabolic benefits of the approach

Moreover, as MnO 2 nanoparticles could be decomposed to harmless water-soluble Mn 2+ ions that are rapidly excreted by kidneys, there should be no long-term toxicity concerns for MnO 2 nanostructures when they are used for in vivo applications, unlike many other non-biodegradable inorganic nanomaterials 23, 29

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