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Description
The DDR induced by oxidative stress also regulates SASP through the activation of NFB signaling, which is one of the main transcription factors triggering SASP, such as IL6 and IL8 [136]

IrajiABensonRRWelchRDONeilBJWoodardJLAyazSI

PE, derived from adrenoic acid (AdA) and arachidonic acid (AA), are key substrates for LPO

In untargeted metabolomics of T1DM patients, 3,4-DHBA was established as an independent risk marker for DR stage progression ( Vitreous-based studies revealed a broad spectrum of upregulated metabolites including allantoin, lactate, proline, dimethylglycine, -ketoglutarate and pyruvate (Tomita et al., 2021), while ascorbate, 5-oxoproline, and fumarate exhibited decreased levels alongside a downregulation of glycolysis and activation of the pentose phosphate pathway ( Metabolic pathways involving carnitine, tryptophan, primary bile acid biosynthesis, pantothenate and CoA biosynthesis, glutathione, glycine, serine, threonine, cysteine, pentose phosphate, methionine, and aminoacyl-tRNA biosynthesis were significantly linked with DR (Sumarriva et al., 2019
doi: 10.1210/me.2010-0373

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