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In vitro Pb exposure disturbs the balance between A production and elimination: the role of AbetaPP and neprilysin

W.Al-SadiR.MaT

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[DOI] [PMC free article] [PubMed] [Google Scholar] 119.Kent S, Bluth RM, Kelley KW, Dantzer R

While the toxicity in HD stems primarily from a toxic gain of function of this mutant protein, the loss of normal HTT function also contributes to the dysfunction and eventual death of projection neurons in the caudate/putamen (known as the striatum in mice) and the cerebral cortex [281]
Gastric cells can protect themselves against oxidative stress by producing scavenger molecules