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Because of these changes in valproate clearance, monitoring of valproate and concomitant drug concentrations should be increased whenever enzyme inducing drugs are introduced or withdrawn

Variants that cause higher CRP are linked to increased risk of some chronic diseases, including cardiovascular disease.[ref] Studies showing that CRP may be causal: In heart disease, CRP may be actively causing atherosclerosis (hardening of the arteries)[ref], thus increasing the risk of heart disease

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Consistent with previous studies (57), daf-2 mutants exhibited a significant increase in fat storage (Fig 3C and D)