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The route of invasion following ingestion is by retrograde transneuronal infection

Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing

These are primarily classified into two structural scaffolds: the C6-C1 type, comprising benzoic acid derivatives (e.g., gallic, protocatechuic, vanillic, and gentisic acids), and the C6-C3 type, which includes the phenylpropanoids [45]

She et al., 2016

Nanoparticles can enhance drug stability, augment mucoadhesion, extend the residence time in GI tract, enhance intestinal permeability and improve the saturation solubility and dissolution rate

In Vivo Deletion of -Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption