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Available from: Hoiting BH et al (1996): Modulation of agonist-induced phosphoinositide metabolism, Ca2+ signalling and contraction of airway smooth muscle by cyclic AMP-dependent mechanisms

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However, recent studies demonstrated that it is possible to re-sensitize tumors using a combination of molecules specifically reverting the aberrant DNA methylation in cancer cells (through drugs inhibiting DNA methyltransferase activity) and cytotoxic drugs ( GST ANTICANCER PRODRUGS An approach to solving drug resistance due to over expression of GST is to design specific GST inhibitors ( The first category consists of prodrugs containing a GSH or GSH-like structure for which a -elimination reaction, catalyzed by GST, releases a cytotoxic compound