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Exclusion criteria were people unable to provide consent, aged under 18, currently pregnant, or who had used hormone therapies (oral contraceptives, GnRH agonist/antagonist, progestins, etc.) in the 3 months preceding study enrollment

doi:10.1007/s10815-013-0168-x

3-nitrotyrosine Protein carbonyls These recommendations are consistent with the broader principle that nonclinical safety evaluation should be aligned with study duration, exposure route, pharmacology, and intended experimental context

Measurable structural healing takes longer