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PubMed: (peer-reviewed) Nguyen T, et al

10.1111/liv.15600 86 MaccioniL.GaoB.LeclercqS.PirlotB.HorsmansY.DE TimaryP.et al (2020)

This rare condition can lead to: low plasma carnitine progressive cardiomyopathy, or heart muscle disease skeletal myopathy hypoglycemia hypoammonemia weak muscles in the hips, shoulders upper arms, legs, neck, and jaw muscles Untreated it is fatal
Anyone reading the 22.7% or 10.8% figures should note these were measured at 68 and 26 weeks respectively not at three months (Aronne et al., 2025

Endogenous hydrogen sulfide and ERK1/2-STAT3 signaling pathway may participate in the association between homocysteine and hypertension

CAN Management strategies for severe CAN, particularly orthostatic hypotension, focus on alleviating symptoms, extending standing time, enhancing physical capacity, and improving overall activity levels rather than solely increasing standing blood pressure
