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It is reported that DAQs can covalently modify Parkin protein in dopaminergic neurons, leading to Parkin protein insolubility and inactivation of its E3 ubiquitin ligase activity [82, 134]

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Li Q, Tan F, Wang Y, Liu X, Kong X, Meng J, et al

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first utilized AA as a matrix by forming Schiff bases from a mixture of AA, niacin, and ammonium citrate, which then react with the basic sites of modified oligodeoxynucleotides for analysis
