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nonetheless, there are a few differences across the models

Additional weight loss of 5-15% of current body weight has been reported in these studies, though results vary considerably and most studies have limited follow-up duration

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Excitotoxic concentrations of the neurotransmitter glutamate lead to stimulation of N-methyl-D-aspartate (NMDA) receptor activity resulting in an increase of intracellular cation (such as Ca2+) levels, and finally to mitochondrial dysfunction (30)

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However, there are no large clinical trials examining its safety or efficacy in autoimmune patients