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Other indicators include a family history of pernicious anaemia or other autoimmune conditions (such as type 1 diabetes mellitus, Hashimotos thyroiditis, or Graves disease), or if the patient is taking metformin, proton pump inhibitors (PPIs), H2 antagonists or has a history of nitrous oxide misuse[15]

10.1200/JCO.2002.99.502 85 GelmonK.EisenhauerE.BryceC.TolcherA.MayerL.TomlinsonE.et al

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In the context of diet-induced obesity, rats exposed to one week of high-fat and fructose diet displayed impaired hippocampal insulin signalling, and smaller hippocampal volume with synaptic degeneration, reduced neuronal processes, and astrogliosis [57]

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3b), which revealed an accumulation of LC3-II together with an increase of p62, compatible with a block of autophagic processes in QN-treated GSCs as compared to control cells