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With respect to TMAO, another study has noted that elevated choline and betaine also seem to contribute to the worsening of left ventricular diastolic dysfunction

Type 1 Diabetes TrialNet and Diabetes Prevention Trial_Type 1 Study Groups Acceleration of the loss of the first-phase insulin response during the progression to Type 1 Diabetes TrialNet and Diabetes Prevention Trial_Type 1 participants Diabetes 62 12: 4179-83