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However, this theory is in dispute because through in vitro techniques using microfluidic chambers, Gornstein and Schwarz have recently found that the distal part of the axon is selectively sensitive to PCTX (Gornstein and Schwarz, 2017)

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A., Tailor, V., Bhide, A

doi: 10.1016/j.jconrel.2019.03.026

Another kind of detoxification pathway, called sulfation or sulfonation, is catalyzed by a group of enzymes, termed sulfotransferases (SULTs), which are responsible for transferring sulfuryl group donated by 3-phosphoadenosine-5-phosphosulfate (PAPS) to the hydroxyl or amine groups [32]