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Furthermore, it increased the expression of cell cycle-related proteins (CDK4 and CyclinD1), vascular endothelial growth factor and fibroblast growth factor 2, indicating enhanced tissue repair and growth
Figure 2 3.1 Endometrial cells 3.1.1 Epithelial cells and EMT The pathophysiology of endometriosis involves EMT, a biological process in which polarized epithelial cells transform to highly motile mesenchymal cells ( 3.1.2 Stromal cells and pro-inflammatory factors Decidualized stromal cells are highlighted in endometriosis ( In addition, endometrial stromal cells account for IL-6 and IL-8 production in endometriotic tissue ( Endometrial stromal cells serve as progenitors of adenomyosis, in which multiple WNT proteins originating from fibroblasts, epithelial cells, and endothelial cells constitute a critical paracrine network (57)

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In medical school you learn about the so-called 50-50-50 rule
