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42 Although less extensively studied, PGC-1 may also play an important role in the regulation of cardiac energy metabolism

sometimes used synonymously with heart failure Cardiac insufficiency - sometimes used synonymously with heart failure Heart failure - the heart's inability to pump enough blood for all of the body's needs Ischemia - inadequate blood supply to an organ or part of the body Observational study - a human research study in which no experimental intervention or treatment is applied, and participants are simply observed over time Oxidative stress - a situation in which the production of reactive oxygen species exceeds the ability of an organism to eliminate or neutralize them Placebo - a chemically inactive substance Randomized controlled trial - a human research study in which participants are assigned by chance alone to receive either an experimental agent (the treatment group) or a placebo (the control group) Reactive oxygen species (ROS) - highly unstable oxygen-containing compounds that react easily with nearby cellular structures, potentially causing damage Authors and Reviewers Originally written in May 2015 by: Giana Angelo, Ph.D

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While it is unclear whether TMAO is directly involved in cardiometabolic diseases, its potential negative effects should be considered

278 : 19071916 Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai L-H

[DOI] [PubMed] [Google Scholar] Winter SC, Szabo-Aczel S, Curry CJ, Hutchinson HT, Hogue R, Shug A