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Consistent with this, the combination of RT and abemaciclib decreased the expression of TGF-1/NF- in MDA-MB-231 and MCF-7 cell lines, which could potentiate apoptosis and further hinder the proliferation of breast cancer cells

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During the ROS production in the polyol pathway, when aldose reductase reduces glucose to sorbitol, excess glucose enters the polyol pathway (Figure 1) (34)

[14] Insulin also plays a role by upregulating the expression of the genes encoding glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase

"Cerebral Manifestations of Vitamin-B12 Deficiency"
