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Suppression of Cx43 hemichannels via intrathecal injection of blockers such as Gap26, Gap27 or Peptide 5 reduces the production of chemokines CXCL1 and CXCL12, as well as cytokines IL-1 and IL-6, in various neuropathic pain models, including nerve injury, chemotherapy-induced and bone cancer models 496,498,504,505

Metabolic relationship between cancerassociated fibroblasts and cancer cells

Proc Am Assoc Can Res 43:1116, 2002

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CAFs also secrete a spectrum of chemokines (e.g., CXCL1, CXCL2) and growth factors that draw in neutrophils and support their pro-tumor functions