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These alterations are associated with specific SZ phenotypes, symptom severity, and treatment response (39, 6668)

28.Henkin RI, Schultz M, Minnick-Poppe L

[DOI] [PMC free article] [PubMed] [Google Scholar] 129.Schulte M.H.J., Wiers R.W., Boendermaker W.J., Goudriaan A.E., van den Brink W., van Deursen D.S., Friese M., Brede E., Waters A.J

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This study documented in humans the variability of the leak pathway in response to systemic inflammation versus the constancy of the pore pathway, and that very large solutes cannot penetrate the paracellular barrier, even in the presence of inflammation

This makes it highly sought after in skin brightening routines