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4 ROS in disease pathophysiology Because of cellular metabolism, eukaryotic cells continuously generate endogenous ROS

Gegotek A, Bielawska K, Biernacki M, Zareba I, Surazynski A, Skrzydlewska E

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In the cell environment, these can promote ROS formation reacting with H 2 O 2 and generating highly reactive OH, in a series of Fenton and Fenton-like reactions

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