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Fujitani K, Ajani JA, Crane CH, Feig BW, Pisters PW, Janjan N, Walsh GL, Swisher SG, Vaporciyan AA, Rice D, Welch A, Baker J, Faust J, Mansfield PF

doi: 10.1007/s00417-002-0571-y

The most profound adverse effect of EDTA is renal toxicity, which clinically manifests as renal failure, proteinuria, and other pathologies

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Simultaneously, there is growing interest in refining modulation of the endocannabinoid system beyond plantderived cannabinoids, focusing on developing compounds that selectively target the cannabinoid Type 2 (CB2) receptor to potentially dampen neuroinflammation [422] or those that inhibit fatty acid amide hydrolase to boost levels of the endogenous cannabinoid anandamide [423], aiming for analgesic efficacy with a reduced psychoactive burden