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Pyruvate maintains energy supply and intracellular redox potential for oocytes, promotes the maturation of oocyte nucleus and cytoplasm, inhibits oocyte aging, and affects oocyte transcriptional activity and lipid metabolism through the formation of acetyl-CoA [39, 139,140,141,142,143,144,145,146,147,148,149,150, 155, 156]

In the senescent state, FOXO4 accumulates in PML (promyelocytic leukemia) nuclear bodies where it binds and sequesters p53, preventing p53 from activating the mitochondrial apoptotic pathway

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doi: 10.3390/biomedicines12081717 299

J Mol Neurosci 65(1):7483

54, 2010 Kurd MF, Patel A, Rihn J, Zhao W, Hilibrand AS, Anderson G, Vaccaro A.R., Weinstein J, Albert TJ.: Treatment of Lumbar Spine Stenosis: Who Decides to have Surgery