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Ghanem and co-workers reported similar observations of increased antioxidant activity and improved blastocyst quality by way of higher embryo development rate and fewer number of apoptotic cells after supplementing LC (1.5 mM, equivalent to 0.3 mg/mL) in culture media of bovine blastocyst during the pre-implantation stage [67]

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For instance, some studies have failed to show any benefit of L-carnitine supplementation on outcomes such as the incidence of heart failure or myocardial reinfarction (CEDIM-2 trial)

Both ACLY and ACSS2 are expressed in CCNE1-driven cells (Extended Data Fig