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Generally, fever is associated with oxidative stress

Encyclopedia of Human Nutrition (Third Edition) pg

Tried multiple prescriptions with no relief

prepared superparamagnetic iron oxide nanoparticles coated with polyethylene glycol, polyethyleneimine, and polysorbate 80 (Tween 80)

For example, chitosan can increase or restore the zeta potential of nanoparticles, which may confer a higher biological interaction of nanoparticles with anionic cell barriers

Finally, melatonin chelates transition metals to reduce the formation of the hydroxyl radical during the Fenton reaction or Haber-Weiss reactions ( Figure 4 ) (86)