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AS-IV can inhibit excessive mesangial cell proliferation and renal fibrosis via the modulation of the TGF-1/Smad/miR-192 signaling pathway ( In contrast, AS-IV inhibits inflammatory cell infiltration and inflammatory cytokine secretion (TNF-, IL-6, and IL-1) by inhibiting inflammation via toll-like receptor 4 (TLR4)/nuclear factor-B (NF-B), both in vivo and in vitro ( in vivo and in vitro experiments have revealed that AS-IV can also effectively ameliorate renal fibrosis by alleviating EMT procession

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Data are represented as the mean SEM from one representative experiment of three ( a d , f h ), or four ( e ) independent experiments

OA can be metabolized by a large range of microbes and bacteria, most of which oxidize the 10-position, but oxidation of the 7-position has also been reported