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The switch from Th1 to Th2 is crucial for survival of the host, indicated by the findings that patients with severe hepatosplenic schistosomiasis have high levels of Th1-associated cytokines [Tumor necrosis factor (TNF), IFN], while asymptomatic patients exhibit high levels of Th2 associated cytokines (IL-4, IL-5, IL-13) and IgE (23)

The intrathecal administration of HGF also exerts positive functional recovery and protection of myelinated areas in animal models of SCI (Kitamura et al., 2011)

Blher, M

However, the function of MSC can vary according to cell culture conditions, donor age, and heterogeneity of the MSC population, resulting in unregulated MSC quality control