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[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Joyce J.M., Mercier L.J., Stokoe M., La P.L., Bell T., Batycky J.M., Debert C.T., Harris A.D

ROS are a major factor of skin aging, involving damage to DNA, the inflammatory response, reduced production of antioxidants, and the generation of matrix metalloproteinases (MMPs) that degrade collagen and elastin in the dermal skin layer, leading to skin wrinkles and reduced elasticity (103)

9 FBP-mediated Rac1 activation depends on RCC2

Later the mice were sacrificed, dissected and histopathologically analyzed

While ExoT has been shown to interfere with PI3K signaling as well, its target remains unclear (Vareechon et al., 2017)

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