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Gclm, glutamate-cysteine ligase modulatory subunit

Kovacs, D

Furthermore, studies on serum from SZ patients showed elevated levels of polyamine oxidase (the enzyme responsible for degrading PAs) (96, 97), while the activities of three enzymes involved in PA synthesisornithine aminotransferase, antizyme inhibitor 1 (AZIN1), and ornithine cyclodeaminase were found to be reduced in the prefrontal cortex of both treated and untreated patients (98), ultimately potentially leading to disrupted polyamine homeostasis

doi: 10.1186/s13048-022-00984-4

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Regulatory Toxicology and Pharmacology, 2012