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Exercise may slow the progression of aging and age-related disorders since it appears to be linked to decreased oxidative stress and increased production of telomere stabilizing proteins

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Follow up studies showed that, while aged APOE4 mice possess bioenergetic deficits in the hippocampus (Hip) and cortex (Ctx), the EC of these mice appears to possess unique counterbalancing mechanisms that allow it to resist these APOE4 -associated decreases in mitochondrial respiration

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discussion 898 Moyle GJ, Sadler M