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Mutations in the following genes are associated with an increased risk of Parkinson's disease: SNCA 33-36 LRRK2 37 PARK2 38 PINK1 39-42 PARK7 43-47 ATP13A2 48-51 Additional research is required to fully elucidate the role of genetics in Parkinson's etiology

Chemistry (Switzerland) 4:345369

Angelica sinensis polysaccharide (ASP) attenuates diosbulbin-B (DB)-induced hepatotoxicity through activating the MEK/ERK pathway

A concentration of 50 mol/L artesunate selectively induces cell death in head and neck cancer cells without affecting normal cells by activating an iron-dependent, ROS-accumulating ferroptosis pathway [139]

Moreover, crizotinib can synergistically increase the MEK-inhibitor AZD6244-induced apoptosis and growth inhibition in vitro and in vivo in KRAS-mutated CRC cells (Van Schaeybroeck et al., 2014)