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Black or tarry stool, visible blood in the stool, vomiting blood, severe abdominal pain, unexplained weight loss, persistent fever, anemia, or progressive swallowing difficulty should be evaluated appropriately

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In cancer cells, significant telomere length extension also occurred through ALT (Alternative Lengthening of Telomeres) activation

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Unlike other cell death pathways, ferroptosis involves the accumulation of oxidized lipids in cell membranes, which GPx4 counters by directly reducing these hydroperoxides to stable alcohols

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