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This change was dependent on prostaglandin D 2 synthase and 15-deoxy- 12,14 -prostaglandin J2 (15d-PGJ 2 ) (5557), highlighting a role for Se in regulating prostaglandin synthesis (56) and promoting the development of M2

82 Five out of the seven studies showed some positive results, but there was significant heterogeneity between individual study results that was not explained by NAC dose, duration of treatment or severity of depressive symptoms at baseline

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