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The function of GPX4 depends on the availability of GSH, whose synthesis and regeneration are under Nrf2 control

Neurons and glial cells operate in a constant state of managing oxidative products, therefore making the CNS inherently vulnerable to redox dysregulation
Moreover, IL-8 contributes to neutrophil activation and NET formation after binding to CXCR2 on neutrophils, thereby causing hyperinflammation

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