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For example, researchers have tested BPC-157 enemas as a treatment for ulcerative colitis in a pair of clinical trials conducted by the Croatian pharmaceutical company PLIVA in the 2000s

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However, it is advised that anyone with a history of medullary thyroid cancer proceed with caution and have regular thyroid monitoring if they choose to take semaglutide

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They are often used for people who have difficulty absorbing B12 from food or supplements due to conditions like pernicious anemia, gastrointestinal disorders (e.g., Crohns disease, celiac disease), or after certain surgeries (e.g., gastric bypass)