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6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide-stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-B dependent pathways and the activation of HO-1/NQO-1 signaling

The role of short chain fatty acids in inflammation and body health

This bioactivity stems from multi-target mechanisms: significant suppression of key pro-inflammatory factors (TNF-, IL-1, IL-6, and iNOS) synthesis/release, enhanced antioxidant capacity ( P 0.05) and showed no significant difference in hepatic TG accumulation versus controls, collectively confirming BSPs metabolic safety and minimal hepatotoxic potential at these doses (He et al., 2025)