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[16] [17] Whereas the latter directly act on the dopamine transporter (DAT) to inhibit the reuptake and/or induce the release of dopamine, bromantane instead acts via indirect genomic mechanisms to produce a rapid, pronounced, and long-lasting upregulation in a variety of brain regions of the expression of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AAAD) (also known as DOPA decarboxylase), key enzymes in the dopamine biosynthesis pathway

thanks MINECO for a Juan de la Cierva Incorporacion fellowship (IJC2020-045506-I)

doi: 10.1152/ajprenal.00513.2015, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 133.Vaziri ND, Liu S-M, Lau WL, Khazaeli M, Nazertehrani S, Farzaneh SH, et al

Similar content being viewed by others Background Glutathione (GSH) is a tripeptide of cysteine, glutamic acid, and glycine, which exists in most plant tissue

Zhang T., Tu S., Zhang X., et al., AmideBased Xanthine Oxidase Inhibitors Bearing an N(1Alkyl3Cyano1HIndol5Yl) Moiety: Design, Synthesis and StructureActivity Relationship Investigation, Bioorganic Chemistry 117 (2021): 105417, 10.1016/j.bioorg.2021.105417