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AON design for NF1 exon skipping and evaluation of exon skipping efficacy For AON design, exon 2 of NF1 was selected as the target, and 13 different AON sequences were designed using Human Splicing Finder and Examine the Secondary Structure of mRNA software

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Under ER stress, however, basal RIDD is inefficient and therefore IRE1s XBP1s splicing activity is initiated, whereas RIDD gradually increases

Importantly, high-potency cannabis products and purified THC extracts are increasingly consumed during adolescence, a period of profound neurodevelopmental vulnerability [8, 9]

They even went above and beyond and did a small repair to the frame as well